Relationship between GHb concentration and erythrocyte survival determined from breath carbon monoxide concentration.

نویسندگان

  • Mark A Virtue
  • Julie K Furne
  • Frank Q Nuttall
  • Michael D Levitt
چکیده

OBJECTIVE Subjects with decreased erythrocyte survival have an unusually low GHb percentage. The goal of this study was to determine whether hyperglycemia, as reflected by GHb percentage, is associated with decreased erythrocyte survival. RESEARCH DESIGN AND METHODS Erythrocyte survival was quantitated in 23 subjects with type 2 diabetes, and these values were correlated with the subjects' GHb percentage. Erythrocyte survival was determined from the difference between the subjects' alveolar carbon monoxide (CO) concentration and atmospheric CO concentration. Reticulocyte counts were obtained in 16 subjects. RESULTS Although the vast majority of the subjects had erythrocyte life spans that fell within the normal range (123 +/- 23 days), there was a highly significant inverse correlation (r = -0.66, P < 0.01) between life span and GHb percentage, with an average decline in life span of 6.9 days for each 1% rise in GHb. The reticulocyte count inversely correlated with erythrocyte life span (r = -0.77, P < 0.01). CONCLUSIONS Hyperglycemia, as evidenced by high GHb percentage, is associated with an appreciable decrease in erythrocyte life span. Because GHb appears to be formed over the lifetime of the erythrocyte, this decreased erythrocyte survival suggests that high GHb percentages may systematically underestimate the true degree of hyperglycemia.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pnm-19: Residential Exposure to Carbon Monoxide and Spontaneous Abortion

Background: The relationship between air pollution exposure and adverse birth outcomes such as low birth weight and IUGR was studied. However, very few studies evaluated the effect of air pollution emissions on spontaneous abortion. We examined association between spontaneous abortion of the first trimester of pregnancy and ambient concentrations of carbon monoxide in Tehran. Materials and Meth...

متن کامل

Parameters of glycemic control and their relationship with zinc concentrations in blood and with superoxide dismutase enzyme activity in type 2 diabetes patients.

OBJECTIVE This study assessed the relationship between the parameters of glycemic control, and zinc concentrations in blood and superoxide dismutase enzyme activity in type 2 diabetes patients. SUBJECTS AND METHODS Seventy-three individuals, aged between 25 and 59 years, were divided into the experimental group (type 2 diabetes patients, n = 36) and control group (n = 37). Plasma and erythroc...

متن کامل

The relationship between single-breath diffusion capacity of the lung for nitric oxide and carbon monoxide during various exercise intensities.

STUDY OBJECTIVES To determine the relationship between single-breath diffusion capacity of the lung for nitric oxide (DLNO) and single-breath diffusion capacity of the lung for carbon monoxide (DLCO), and to determine the single-breath DLNO/DLCO ratios during rest and at several exercise intensities using a commercial lung diffusion system that uses electrochemical cells to analyze gases. SET...

متن کامل

A Modified Carbon Monoxide Breath Test for Measuring Erythrocyte Lifespan in Small Animals

This study was to develop a CO breath test for RBC lifespan estimation of small animals. The ribavirin induced hemolysis rabbit models were placed individually in a closed rebreath cage and air samples were collected for measurement of CO concentration. RBC lifespan was calculated from accumulated CO, blood volume, and hemoglobin concentration data. RBC lifespan was determined in the same anima...

متن کامل

EFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS

Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was mea...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Diabetes care

دوره 27 4  شماره 

صفحات  -

تاریخ انتشار 2004